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Live with Rebecca Culshaw Smith

On Viral Load & the PCR Technology
Rebecca Culshaw Smith's avatar
Rebecca Culshaw Smith
Apr 11, 2025
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Cross-post from The Real AIDS Epidemic
Enjoy this livestream! Dr. Rebecca Culshaw—whose Ph.D. is in mathematics—dives into the 1995 Nature paper that not only created a "lazy" mathematical model for how HIV (allegedly) kills T4 cells but also resulted in thousands of people being treated with toxic protease inhibitor drugs (no longer prescribed). Rebecca's explanation is so clear that even a non-math person like me easily grasped how one faulty—but highly publicized—mathematical model could have negatively influenced AIDS research and treatments for 30 years. It's an object lesson in how easily medical research can go very, very wrong and how difficult such mistakes are to correct. -
Neenyah Ostrom

Thank you

Chief Justice of Nuremberg 2.0
,
Akil
,
Andrew
, and many others for tuning into my live video! Join me for my next live video in the app.

Here are links to the papers referred to:

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

History of viral load and different cut-offs

Recent advances in poor HIV immune reconstitution: what will the future look like?

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