Hi Rebecca, my name is David. I'm a writer who's interested in the intersection of science and politics. I've written about AIDS before (article link below). While I don't take a position on the etiology of the disease I'm very interested in your work and the history of AIDS dissent. Please email me at dfgrove86@gmail if you'd be interested in talking more. Thanks
In the previous post I examined what should be one of the most famous papers in scientific history, ‘CYTOMEGALIC INCLUSION DISEASE AND PNEUMOCYSTIS CARINII INFECTION IN AN ADULT.’
This October 1960 Lancet paper showed that, no matter what the ‘HIV Causes AIDS’ dogmatists claimed, AIDS was not a new condition. Only the afflicted demographics were new.
In the 1960s the association between PCP pneumonia and CMV (as per the original 5 cases in June 1981) became more apparent.
A 1964 paper, Transplantation Pneumonia, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095840/pdf/nihms250017.pdf studied distinct pneumonitis in six renal transplant recipients. Autopsy of the single case in which death occurred revealed Pneumocystis carinii pneumonia and disseminated cytomegalic inclusion body disease.
The coexistence of Pn carinii and cytomegalovirus in pneumonia has been noted frequently. Ten of 16 infants and six of 15 adults with generalized cytomegalovirus infection were found to have Pneumocystis pneumonia. In addition, generalized cytomegalovirus infection can be demonstrated in 25% of cases of Pneumocystis pneumonia. The association is so constant that it has been questioned whether cytomegalovirus can cause pneumonia in adults in the absence of Pn carinii.
It is believed that the six cases of pneumonia reported here are compatible with Pn carinii infection in patients whose defense mechanisms have been impaired by immunosuppressive drug therapy. The cytomegalovirus may have been present and contributed to the pathological process in some of the nonfatal cases.
Both of the infectious agents are opportunistic; that is, they usually produce clinical disease only when host defense mechanisms are depressed. Whether there are, in addition to the suppressive drug therapy, immunologic factors unique to organ transplant recipients which contribute to the development of these pneumonic processes is a matter of speculation.’
The 1967 paper ‘Death After Transplantation, An Analysis of Sixty Cases’
‘Cytomegalovirus and Pneumocystis carinii were found with extraordinary frequency. One patient, died of hemorrhagic pancreatitis, without evidence of infection other than cytomegalovirus, eighty-three days after receiving a transplant.’
I hope you have enjoyed CascAIDS post number twelve.
Next time, in CascAIDS post number thirteen, ‘The Smoking Guns’, I will examine ‘transplant AIDS’ associated with CMV, in the 1970s.
Hi Rebecca, my name is David. I'm a writer who's interested in the intersection of science and politics. I've written about AIDS before (article link below). While I don't take a position on the etiology of the disease I'm very interested in your work and the history of AIDS dissent. Please email me at dfgrove86@gmail if you'd be interested in talking more. Thanks
https://compactmag.com/article/how-leftists-became-big-pharma-s-shock-troops
Hello and welcome to my twelfth ‘CascAIDS’ post.
In the previous post I examined what should be one of the most famous papers in scientific history, ‘CYTOMEGALIC INCLUSION DISEASE AND PNEUMOCYSTIS CARINII INFECTION IN AN ADULT.’
This October 1960 Lancet paper showed that, no matter what the ‘HIV Causes AIDS’ dogmatists claimed, AIDS was not a new condition. Only the afflicted demographics were new.
In the 1960s the association between PCP pneumonia and CMV (as per the original 5 cases in June 1981) became more apparent.
A 1964 paper, Transplantation Pneumonia, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095840/pdf/nihms250017.pdf studied distinct pneumonitis in six renal transplant recipients. Autopsy of the single case in which death occurred revealed Pneumocystis carinii pneumonia and disseminated cytomegalic inclusion body disease.
The coexistence of Pn carinii and cytomegalovirus in pneumonia has been noted frequently. Ten of 16 infants and six of 15 adults with generalized cytomegalovirus infection were found to have Pneumocystis pneumonia. In addition, generalized cytomegalovirus infection can be demonstrated in 25% of cases of Pneumocystis pneumonia. The association is so constant that it has been questioned whether cytomegalovirus can cause pneumonia in adults in the absence of Pn carinii.
It is believed that the six cases of pneumonia reported here are compatible with Pn carinii infection in patients whose defense mechanisms have been impaired by immunosuppressive drug therapy. The cytomegalovirus may have been present and contributed to the pathological process in some of the nonfatal cases.
Both of the infectious agents are opportunistic; that is, they usually produce clinical disease only when host defense mechanisms are depressed. Whether there are, in addition to the suppressive drug therapy, immunologic factors unique to organ transplant recipients which contribute to the development of these pneumonic processes is a matter of speculation.’
The 1967 paper ‘Death After Transplantation, An Analysis of Sixty Cases’
http://d-scholarship.pitt.edu/3526/1/31735062124585.pdf was explicit:
‘Cytomegalovirus and Pneumocystis carinii were found with extraordinary frequency. One patient, died of hemorrhagic pancreatitis, without evidence of infection other than cytomegalovirus, eighty-three days after receiving a transplant.’
I hope you have enjoyed CascAIDS post number twelve.
Next time, in CascAIDS post number thirteen, ‘The Smoking Guns’, I will examine ‘transplant AIDS’ associated with CMV, in the 1970s.
regards,
Paul