PrEPVacc has Failed

Is anyone surprised?

This was always going to happen, and now it has.

‘Last roll of the dice’ for a near-term HIV vaccine fails

We discussed PrEPVacc back in February. In case you don’t recall, the PrEPVacc study has been ongoing in four African countries, and aimed to examine the effects of both a new “HIV vaccine” and provide a comparison between “good Truvada” (TAF) and “bad Truvada” (TDF).

Well, it has failed, and is about to be abandoned for futility. Yet again. Let’s dive in.

A study billed as the last chance to develop an HIV vaccine this decade has been shut down, investigators announced Wednesday at a conference in Harare, Zimbabwe.

The trial, known as PrEPVacc, was testing two different vaccine regimens on about 1,500 volunteers in East and Southern Africa. After multiple other high-profile trials failed, a PrEPVacc investigator described the study this summer as “the last roll of the dice” for an HIV vaccine until the 2030s. 

Do you suppose they’re really going to stop testing “HIV vaccines” until 2030? Given the urgent push for “long acting injectable PrEP,” perhaps that may eventuate. The “PrEP as vaccine” scheme is unrolling at warp speed.

This next excerpt is interesting. Emphasis is mine.

Although disappointing, the news may not surprise many HIV vaccine researchers. PrEPVacc was seen as a pioneering study, both as one of the first large, African-led HIV vaccine trials and one of the first trials to incorporate PrEP, the daily antiviral pills that can dramatically reduce the risk of HIV infection. 

But the trial used older vaccine designs some scientists doubted would provide adequate protection. 

Ah, there it is. They’re finally saying the quiet part out loud—“older vaccine designs” are now old news and ineffective against these wily new pathogens. The ever-wider net we continue to cast for alleged viral diseases has gotten to the point that we are classifying things like endogenous virus-like particles and “HIV-associated genetic material” as true exogenous pathogens, and calling them “infectious,” when they are not, and therefore cannot, per traditional vaccine science, be prevented by “traditional vaccines.” So how do the drug companies manufacturing vaccines plan to deal with this conundrum? Well, let’s start producing them using “novel vaccine design.” Sound familiar yet?

This article is full of interesting lines. This one is short, but I’m putting it in a block quote because it’s amazing:

With the failure, there are now “no HIV vaccines being trialled for efficacy anywhere in the world,” PrEPVacc investigator Pontiano Kaleebu said in a statement. 

There are currently no HIV vaccines being trialed for efficacy anywhere in the world. Is this the first time since AIDS began that this has been the case? And you know why. It’s because there is no HIV to vaccinate against. Anyone already “HIV positive” already has the antibodies. But instead of admitting that this is a clear indication that HIV is simply a red herring, the establishment decided to double down and just prescribe antiretrovirals to anyone that wants them, HIV positive or not. Who needs a vaccine when you have designer drugs? It’s all so insidious.

The new strategies include sending HIV “wanted” posters to a specific set of immune cells by encoding them in another, more benign chronic virus. More popular is an approach called germline targeting, where researchers give a series of different jabs designed to nudge the immune system toward making the perfect, HIV-snaring antibodies. 

“Sending HIV ‘wanted’ posters to a specific set of immune cells?” The continued anthropomorphization of this alleged virus just astounds me. Also, “a series of jabs”? Is this the language we are going to use in medicine moving forward? A series of jabs? I wonder how this “series of jabs” will improve on the already existing antibody response to “HIV” (whatever that is). (Spoiler: it will fail, and be abandoned for futility.)

This next paragraph tells you everything you need to know (emphasis mine).

Some researchers are skeptical, however, that the new technologies will ever lead to an HIV vaccine. Even as the HIV vaccine field has struggled for 40 years, companies have developed other methods of stopping transmission for extended periods: Forms of PrEP that can virtually eliminate the risk of infection with an injection every couple months. Biannual and annual injections are now in development.

You know that this is where they are going to go with this. They have no choice. After something like a hundred HIV vaccine trials have failed, the writing is on the wall. How to deal with it? Develop medications that can be used instead of vaccines, despite the fact that none of this makes any sense, and market them as “long lasting injectables.” We’re already used to being encouraged to take a flu vaccine every year forever, why not a “long lasting injectable” to prevent AIDS? What could go wrong?

Finally:

Long-acting PrEP could raise the bar for how effective an HIV vaccine has to be, while also making it more difficult to run vaccine trials. Researchers, for example, may no longer be able to compare new shots to placebo.

Placebo controlled clinical trials, which have traditionally been the gold standard in drug and vaccine development, have been in their death throes for decades now, and I think that this methodology is now officially dead, which is a complete tragedy for evidence-based science and medicine. The entire mess is very tricky to unravel, but I will say that the angry AIDS activists and their insistent push for approval of dangerous drugs via fast-tracked (extremely fast-tracked), (almost entirely) non-placebo-controlled clinical trials, have a lot to answer for. We are watching the continued undermining of traditional, empirical science by drug companies and the activists that they have in their thrall. This needs to stop before the disaster gets even worse.

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