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Christoph.'s avatar

About the question from X Man. The problem with saying ARV's are altering a sick person's health in a positive way and thus it means it's because of a suppression of 'HIV', is that these drugs clearly have multiple actions in the body. In general, doctors frequently prescribe various drugs 'off label' because this is true of many pharmaceuticals. In fact this is how Ozempic became a big time anti-obesity drug. The ARVs can have direct antimicrobial actions, much like broad spectrum antibiotics, because of this non-specific effect in the body. Also, the fact that these ARVs are associated with serious liver, kidney and heart problems is testament to the fact that the inverse of this situation is also true, give them to otherwise healthy people and watch them get sick.

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Christoph.'s avatar

Regarding the PF Stevens question about stopping antiretrovirals. I think it's quite possible this could happen, theoretically. In fact recently it came to light that Paxlovid has as part of its makeup an HIV drug that specifically is there to slow down the liver's ability to clear the drugs from the system. These drugs at the same time are damaging the liver and making it 'leaky', bile is leaking into the bloodstream where it doesn't belong causing all kinds of havoc in the body. Type 2 diabetics for instance have much higher levels of serum bile acids than non-diabetics. There's a series of tests for this called Serum Bile Acids tests, it's not a theoretical thing that this happens. So you quit the drugs, and the liver 'wakes up', of sorts, and begins the process of trying to rid itself and the body of toxins at a faster pace, through the bile (that's how it gets rid of a lot of toxins), but they're backing up into the body now where they don't belong making you really really sick. This sickness is then blamed on 'HIV' rebounding. I think this is is one plausible mechanism in my mind.

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